Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

Autor:	G O Cory, L MacCarthy-Morrogh, S Banin, I Gout, P M Brickell, R J Levinsky, C Kinnon, R C Lovering
Rok vydání:	1996
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 157:3791-3795
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.157.9.3791
Popis:	Wiskott-Aldrich syndrome is an X-linked combined immunodeficiency affecting cells of several different hemopoietic lineages. The Wiskott-Aldrich syndrome protein (WASP), which has no homology with any other known protein families, is rich in proline motifs known to contribute to Src homology 3 binding sites. However, its function has not been determined. The Tec family of cytoplasmic tyrosine kinases, which include Btk (the X-linked agammaglobulinemia gene), Itk, and Tec, is thought to be involved in lymphoid cell signaling pathways. In this work, we show binding of WASP to the Src homology 3 domains of Btk, Itk, Tec, Grb2, and phospholipase C-gamma, which suggests a function for WASP in lymphoid cell signaling.
Databáze:	OpenAIRE
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