Proliferation and cytotoxicity of thymus lymphocytes in vitro

Autor:	A. V. Sergeev, A. A. Ivanov, S. N. Bykovskaya, M. O. Raushenbakh, L. M. Luchanskaya
Rok vydání:	1977
Předmět:	education.field_of_study Chemistry Population Stimulation Spleen General Medicine Molecular biology General Biochemistry Genetics and Molecular Biology In vitro Cytolysis Immune system medicine.anatomical_structure Immunology medicine Cytotoxic T cell education Cytotoxicity
Zdroj:	Bulletin of Experimental Biology and Medicine. 84:1311-1314
ISSN:	1573-8221 0007-4888
Popis:	The proliferative and cytolytic activity of lymphocytes from the spleen and intact thymus was compared after alloimmunization. The number of living cells and of DNA-synthesizing cells in a monoculture of thymocytes was 90–97% less, and in a mixed culture of thymus cells about 80% less that the corresponding number of spleen cells. The index of stimulation of immune thymocytes was several times greater than that of immune spleen cells. The peak of cytotoxicity was observed on the fourth to fifth day of stimulation, when the cytolytic activity of the immune thymocytes was close to the activity of immune spleen cells. The low DNA synthesis and the considerable cytotoxic activity of the immune thymocytes mean that stimulation of thymus cells in vitro can be used to obtain a cell population with a high content of cytolytic T lymphocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::37eb62819c34d2048d048e109cc91bef https://doi.org/10.1007/bf00805893 Zobrazit plný text záznamu Full text from SpringerLink