EHDP treatment of Paget's disease
| Autor: | Hiroaki Tanaka, Yoshiharu Oka, Shinichi Mishima, Kenzo Ito |
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| Rok vydání: | 1987 |
| Předmět: | |
| Zdroj: | Orthopedics & Traumatology. 35:1071-1075 |
| ISSN: | 1349-4333 0037-1033 |
| DOI: | 10.5035/nishiseisai.35.1071 |
| Popis: | Monostotic paget's disease involving the entire right pelvis was encountered. The therapeutic effect of EHDP is described together with literature reviews.The patient was a 51-year-old man with an elevated Al-p level and mild dull pain in the right pelvis. Despite treatment with pig calcitonin from Apr, 1981, the Al-p level that had once been controlled began to reelevate. The treatment was changed to eel calcitonin, but as this again resulted in reelevation of Al-p after a temporary reduction, administration of eel calcitonin was suspended. In Feb, 1985, Al-p and urinary hydroxyproline rose to 46.5 (K. A. U.) and 101mg/day respectivery with growth of dull pain in the lesion. As we had access to EHDP, oral administration of 400mg/ day (6.3mg/kg) was begun from Feb, 1985. From 2 months after EHDP therapy, it improved Al-p, normalized urinary hydroxyproline and remitted local pain. Although administration was suspended after 6 months (end of Aug) for fear of its adverse effect on bone metabolism, Al-p showed a tendency of gradual decrease (18.9 K. A. U.) even one month after suspension. |
| Databáze: | OpenAIRE |
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