Synthesis and some CNS activities of new benzofuranylacryloylpiperazines

Autor: G. Lamotte, J. M. Gillardin, F. Lepage, S. Risse, Pierre Demerseman, Daniel Dauzonne, R. Pointet
Rok vydání: 1995
Předmět:
Zdroj: European Journal of Medicinal Chemistry. 30:53-59
ISSN: 0223-5234
DOI: 10.1016/0223-5234(96)88209-2
Popis: Summary A series of novel benzofuranylacryloylpiperazines, which are structurally related to both cinnamamide derivatives and befuraline, have been prepared as their hydrochlorides. Their anticonvulsant and antidepressant activities against seizures induced by electroshock and against tetrabenazine-induced palpebral ptosis have been evaluated in mice. Some of them revealed interesting potencies since, although they are less active than the reference drugs, they exhibited a higher protective index.
Databáze: OpenAIRE