Synthesis and some CNS activities of new benzofuranylacryloylpiperazines

Autor:	G. Lamotte, J. M. Gillardin, F. Lepage, S. Risse, Pierre Demerseman, Daniel Dauzonne, R. Pointet
Rok vydání:	1995
Předmět:	Pharmacology Stereochemistry Chemistry medicine.medical_treatment Organic Chemistry Central nervous system General Medicine Befuraline Chemical synthesis Anticonvulsant medicine.anatomical_structure Drug Discovery Convulsion medicine Antidepressant medicine.symptom medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 30:53-59
ISSN:	0223-5234
DOI:	10.1016/0223-5234(96)88209-2
Popis:	Summary A series of novel benzofuranylacryloylpiperazines, which are structurally related to both cinnamamide derivatives and befuraline, have been prepared as their hydrochlorides. Their anticonvulsant and antidepressant activities against seizures induced by electroshock and against tetrabenazine-induced palpebral ptosis have been evaluated in mice. Some of them revealed interesting potencies since, although they are less active than the reference drugs, they exhibited a higher protective index.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::37e05562cb59498051a036a17903a7fc https://doi.org/10.1016/0223-5234(96)88209-2 Zobrazit plný text záznamu Full Text from ScienceDirect