Exploring the limits of hepatic surgery for alveolar echinococcosis—10-years’ experience in an endemic area of Austria

Autor:	Dietmar Öfner, Herbert Auer, Stefan Schneeberger, Andrea Brunner, Michaela Plaikner, Eva Gassner, Alexander Loizides, Stefanie Kuscher, Irmgard E. Kronberger, Marijana Ninkovic
Rok vydání:	2019
Předmět:	medicine.medical_specialty biology Incisional hernia business.industry Perioperative Vascular surgery medicine.disease Echinococcus multilocularis biology.organism_classification Cardiac surgery Surgery 03 medical and health sciences 0302 clinical medicine Pharmacotherapy 030220 oncology & carcinogenesis medicine 030211 gastroenterology & hepatology Stage (cooking) business Abdominal surgery
Zdroj:	European Surgery. 51:189-196
ISSN:	1682-4016 1682-8631
Popis:	Hepatic alveolar echinococcosis is a slow-growing, destructive parasitosis for which radical surgical resection is currently the only curative treatment. In case of complications by infiltrated vascular or biliary structures, interventional techniques are used. Pharmacotherapy is recommended postoperatively and for inoperability. The rare zoonotic occurs in the northern hemisphere and still poses a challenge in diagnostic and therapeutic management. Based in an endemic area in Austria, we evaluated a decade of surgical treatment for alveolar echinococcosis (AE) at our department. Clinical data of patients undergoing hepatic resection for AE at our department between 2005 and 2014 were collected. Every diagnosis was again verified by histology and PCR. The PNM staging of preoperative imaging was done in six-eye principle. This study was approved by the local Ethics Committee of the Medical University Innsbruck (registration number 20170307-1537). Nine of 12 patients had an R0 resection. In one case, cure was achieved by a combination of surgery and radiofrequency ablation, one patient had R2 resection due to unexpected AE spread and another patient underwent salvage operation with lethal outcome. Three patients experienced early postoperative complications. Late postoperative complications included incisional hernia and cholestatic hepatopathy. 9 patients have been disease free for a mean period of 6 years. The relevance and perioperative risks of an extensive AE resection and avoidance of R2 resections are reflected in the present study. Determination of PNM stage and evaluation of in-all resectability build the foundation for successful surgical treatment even in an advanced AE stage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::37d86351da35074718b4897daa7b9f50 https://doi.org/10.1007/s10353-019-0596-7 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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