Preeclampsia Associated With Antiphospholipid and Anti-β2-Glycoprotein-I Antibodies and Postpartum Thrombocytopenia, Cardiac Dysfunction, and Blindness: A Case Report
| Autor: | H. J. Schäfer, H. P. Moecke, P. Schmidt-Rhode, T. Hamdosch, J. Jenning |
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| Rok vydání: | 2002 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty Vascular disease Obstetrics business.industry Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Preeclampsia Pathogenesis medicine.anatomical_structure Antiphospholipid syndrome Immunopathology Placenta embryonic structures Maternity and Midwifery Immunology medicine Gestation business reproductive and urinary physiology |
| Zdroj: | Geburtshilfe und Frauenheilkunde. 62:592-595 |
| ISSN: | 1438-8804 0016-5751 |
| Popis: | We describe a patient with severe preeclampsia and postpartum complications in whom we investigated a panel of autoimmune reactions. Case Report: A 27-year-old primigravida was referred at 37 weeks' gestation because of severe preeclampsia. A cesarean section was performed. Postpartum the patient developed severe cardiac dysfunction, thrombocytopenia, eclamptic seizures, and blindness. Immunohistochemical studies of the placenta showed marked deposition of terminal C5b-9 complement complex in intervillous fibrin and in intravillous stroma. Conclusion: The generation of C5b-9 complement complex may be involved in the pathogenesis ofpreeclampsia-eclampsia. |
| Databáze: | OpenAIRE |
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