Impact of Controlled Ovarian Hyperstimulation on Thyroid Function
| Autor: | Marinus J.C. Eijkemans, Kathrin Fleischer, Frank H. de Jong, Femke P Hohmann, Alex F Muller, Bart J.C.M. Fauser, Joop S. E. Laven |
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| Rok vydání: | 2014 |
| Předmět: |
endocrine system
medicine.medical_specialty In vitro fertilisation Endocrine disease endocrine system diseases biology business.industry media_common.quotation_subject medicine.medical_treatment Ovarian hyperstimulation Controlled ovarian hyperstimulation medicine.disease Thyroxine-binding globulin Endocrinology Reproductive Medicine Thyroid-stimulating hormone Internal medicine medicine biology.protein Thyroid function business hormones hormone substitutes and hormone antagonists Menstrual cycle media_common Biomedical engineering |
| Zdroj: | Reproductive Biology Insights. 7:9-16 |
| ISSN: | 1178-6426 |
| Popis: | OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E2), thyroxine binding globulin (TBG), free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E₂, TBG, and TT₄ were significantly higher; midluteal FT₄ was significantly lower (mean difference: -1.46 pmol/L; P < 0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT₄ and higher midluteal TSH levels compared to the natural cycle. |
| Databáze: | OpenAIRE |
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