Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis
| Autor: | Foo Y. Liew, Roger D. Sturrock, Max Field, Bernard P. Leung, Iain B. McInnes |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
biology
business.industry T cell Arthritis General Medicine medicine.disease Molecular biology General Biochemistry Genetics and Molecular Biology TCIRG1 Interleukin 21 medicine.anatomical_structure Interleukin 15 Immunology biology.protein Medicine Cytotoxic T cell Tumor necrosis factor alpha Antibody business |
| Zdroj: | Nature Medicine. 3:189-195 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/nm0297-189 |
| Popis: | Tumor necrosis factor-alpha occupies a central role in rheumatoid arthritis (RA) pathogenesis. We now report that interleukin-15 (IL-15) can induce TNF-alpha production in RA through activation of synovial T cells. Peripheral blood (PB) T cells activated by IL-15 induced significant TNF-alpha production by macrophages via a cell-contact-dependent mechanism. Freshly isolated RA synovial T cells possessed similar capability, and in vitro, IL-15 was necessary to maintain this activity. IL-15 also induced direct TNF-alpha production by synovial T cells. In contrast, IL-2 induced significantly lower TNF-alpha production in either cell-contact-dependent or direct culture, and IL-8 and MIP-1 alpha were ineffective. Antibodies against CD69, LFA-1 or ICAM-1 significantly inhibited the ability of T cells to activate macrophages by cell contact. |
| Databáze: | OpenAIRE |
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