The Effect of Methimazole on the White Blood Cells, Bursa of Fabricius, Thyroid Gland, and Body Weight of Young Chickens
| Autor: | Bruce Glick, R. L. Haynes |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Thyroid Thyroidectomy chemistry.chemical_element General Medicine Iodine Body weight Rash Thiouracil Methimazole chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Animal Science and Zoology Bursa of Fabricius medicine.symptom business medicine.drug |
| Zdroj: | Poultry Science. 39:1495-1501 |
| ISSN: | 0032-5791 |
| DOI: | 10.3382/ps.0391495 |
| Popis: | 1-METHYL- 2 -MERCAPTOIMIDAZOLE is the chemical name for a relatively new goiterogen. Its pharmaceutical name is methimazole, and its trade name is Tapazole. In this report it will be referred to as methimazole. During the course of testing a number of antithyroid drugs by the radioiodine method, it was observed by Stanley and Astwood (1949) that methimazole was remarkably active. As little as 0.5 mg. exerted a pronounced inhibitory effect on iodine accumulation, and doses of 5.0 mg. completely inhibited the iodine uptake for nearly twenty-four hours. It was estimated that the activity of methimazole was approximately 100 times that of thiouracil. Methimazole has been used successfully in human medical practice as an aid in preparing patients suffering from hyperthyroidism for thyroidectomy, and as treatment for patients where thyroidectomy was not recommended, Rosendaum and Reveno (1952). Some of the side effects encountered from administering methimazole to humans are skin rash, … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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