Effects of ethanolic extract of Waltheria indica aerial parts on some liver and kidney function indices in albino rats
| Autor: | J L Hamidu, Joseph Olusegun Ayo, Alexander B. Adelaiye, M.S. Abubakar . |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Bilirubin 030106 microbiology 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences chemistry.chemical_compound Animal science Oral administration White blood cell Genetics Medicine Molecular Biology Chronic toxicity Mean corpuscular volume biology medicine.diagnostic_test business.industry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Alanine transaminase chemistry biology.protein Waltheria indica business Hypoactivity Agronomy and Crop Science Biotechnology |
| Zdroj: | African Journal of Biotechnology. 17:626-632 |
| ISSN: | 1684-5315 |
| DOI: | 10.5897/ajb2017.15974 |
| Popis: | This study evaluated the toxicological effects of chronic treatment with ethanolic extract of Waltheria indica aerial portion on body weight, hematological and biochemical parameters in albino rats using standard methods. Rats treated with 400 mg/kg body weight (bw)/day of the extract showed no behavioural changes. However, there was general reduction of activity in rats given 800 and 1,600 mg/kg bw/day of the extract. Also, the LD50 treated rats exhibited hypoactivity, grooming, prostration and irritation during treatment in the third and fourth weeks of treatment period. The data on body weight changes indicated that there were no significant differences in body weight between the control group and groups that received different doses of the extract (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|