| Popis: |
Tuberculosis (TB) disease can progress in a multitude of directions subject to various intrinsic and extrinsic factors on host immune system, starting from genetic insult to nutritional and physiological state of the host. This study was conducted to assess the major socio-demographic characteristics and hematological and biochemical abnormalities for their role in susceptibility to pulmonary tuberculosis. 94 study subjects were enrolled in this study, of which 34 subjects comprised of new case Active Pulmonary TB (PTB), 30 with latent tuberculosis (LTB) and 30 healthy household subjects. All related demographic, socio-economic along with clinical data were collected through a predesigned and pre-tested questionnaire. (2-3) ml blood was drawn from each study subject aseptically for routine blood examination using automated cell counter. The male: female ratio for PTB=2.1:1, LTB=1.3:1, household contacts=0.7:1. Mostly Hindus (97.05% PTB, 90% LTB, 93.33% healthy) with higher proportion of married subjects among all groups (73.53% PTB cases, 70% LTB, 63.33% healthy) observed. 65% of PTB patients were illiterate or educated up to primary level with 40% of both LTB and household contacts with secondary education. 11.76% of PTB patients and 33.33% with LTB had family history of the disease. Prevalence of TB was higher among the poorer strata with 76.47% and 70% respectively in those with PTB and LTB. Male gender, marriage, positive family history and basic-education/illiteracy were found to be associated with disease susceptibility. Anemia and leukocytosis were observed among PTB patients as compared to those with LTB and household contacts. |
