Palladium-Catalyzed Stereoselective Defluorination Arylation/Alkenylation/Alkylation of gem-Difluorinated Cyclopropanes
| Autor: | Yao Fu, Ebrahim-Alkhalil M. A. Ahmed, Tian-Jun Gong, Ayman M. Y. Suliman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification 010405 organic chemistry Chemistry Organic Chemistry chemistry.chemical_element Conjugated system Alkylation 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Organic chemistry Stereoselectivity Physical and Theoretical Chemistry Fluoride Alkyl Palladium |
| Zdroj: | Organic Letters. 21:5645-5649 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A palladium-catalyzed cross-coupling of gem-difluorinated cyclopropanes with boronic acids, providing the corresponding arylated/alkenylated/alkylated 2-fluoroallylic scaffolds, is generated. This new approach has good functional group compatibility for both gem-difluorinated cyclopropanes and boronic acids; thus, an array of synthetic building blocks of monofluoroalkene scaffolds including conjugated fluorodiene and skipped fluorodiene gave good yields with high Z-selectivity. Moreover, proficient application was described for monofluoroalkene, whereas the corresponding alkyl fluoride was constructed through hydrogenation. |
| Databáze: | OpenAIRE |
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