Nodular hepatocellular carcinoma. Treatment with subsegmental intraarterial injection of iodine 131-labeled iodized oil
| Autor: | Ki Whang Kim, CY Park, Hyung Sik Yoo, Jongmin Lee, Heung Jai Choi, John J.K. Loh, Kyong Sik Lee, Jung Ho Suh, Chan Ii Park, Byung Soo Kim |
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| Rok vydání: | 1991 |
| Předmět: |
Cancer Research
medicine.medical_specialty Abdominal pain Gastrointestinal tract Lung medicine.diagnostic_test business.industry Thyroid chemistry.chemical_element medicine.disease Iodine medicine.anatomical_structure Oncology chemistry Hepatocellular carcinoma Angiography medicine Lipiodol Radiology medicine.symptom business medicine.drug |
| Zdroj: | Cancer. 68:1878-1884 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19911101)68:9<1878::aid-cncr2820680905>3.0.co;2-d |
| Popis: | Internal radiation therapy with subsegmental arterial injection of iodine 131(131I)-labeled iodized oil (Lipiodol; Laboratorie, Guerbet, France) was evaluated in 24 patients with nodular hepatocellular carcinoma (HCC) ranging from 2.5 to 8.0 cm in size. 131I Lipiodol (555 to 2220 MBq in 3 to 8 ml) was injected depending on the tumor size. Tumor reduction was seen in 88.9% of tumors smaller than 4.0 cm in diameter, 65.5% of tumors between 4.1 to 6.0 cm, and 25.0% of tumors larger than 5.1 cm. The tumor size reduction corresponded to the gradual drop of serum alpha-fetoprotein (AFP) levels and devascularization on follow-up angiography. Adverse reactions from treatment included fever, mild abdominal pain, nausea, and elevation of transaminases. These were mild and well tolerated by patients. This method provided long-term local control without complications related to the thyroid, lung, gastrointestinal tract, and bone marrow. |
| Databáze: | OpenAIRE |
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