| Autor: |
Shinichi Terada, Yasuhisa Sakurai, Teruo Okano, Naoto Takemura, Ken Suzuki, Mikihiro Nozaki |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems ISBN: 9784431658856 |
| DOI: |
10.1007/978-4-431-65883-2_62 |
| Popis: |
We were already reported that the amphiphilic block copolymer composed from 2-hydroxyethylmathacryrate and styrene(HSB) which formed micro-domain structure show excellent nonthombogenicity. In this study, we applied HSB coated small vascular graft for vain. The grafts were implanted into the rabbits inferior vena cave. After 1 week implantation, the round shape HSB coated graft tube shows 100% patency after 1 week implantation. No thrombus was observed on the anastomotic site and the grafts surfaces. When the edges were rounded, the damage of natural blood tube and turbulent flow were perverted, the HSB coat graft tubes keep patency more than 1 week in low flow rabbit vain. The cross-section of graft was observer with TEM. After staining with OsO4, only monolayer-like protein layer(about 200A) were observed on surface. The monolayre-like absorbed protein layer improved blood compatibility without persudointima formation. Thus the HSB coated graft could be a promising small vessel prosthesis even in vaines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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