Risk Factors and Outcomes Associated With Identification of Aspergillus in Respiratory Specimens From Persons With HIV Disease
| Autor: | Ben L. Browdy, Jeanne M. Wallace, Paul A. Kvale, Rosemarie Lim, Jeffrey Glassroth, Lee B. Reichman, Philip C. Hopewell, Mark J. Rosen |
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| Rok vydání: | 1998 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Respiratory disease Case-control study Critical Care and Intensive Care Medicine medicine.disease Aspergillosis Acquired immunodeficiency syndrome (AIDS) Internal medicine Immunology medicine Clinical significance Viral disease Cardiology and Cardiovascular Medicine business Cohort study Cause of death |
| Zdroj: | Chest. 114:131-137 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.114.1.131 |
| Popis: | Study objectives To examine the significance of previously suggested risk factors and assess outcomes associated with Aspergillus identification in respiratory specimens from HIV-seropositive individuals. Design This was a nested case-control study. Patients who had Aspergillus species identified in respiratory specimens were matched at the time of study entry 1:2 with control subjects according to study center, age, gender, race, HIV transmission category, and CD4 count. Setting The multicenter Pulmonary Complications of HIV Infection Study. Participants HIV-seropositive study participants. Measurements and results Between November 1988 and March 1994, Aspergillus species were detected in respiratory specimens from 19 (1.6%) participants. The rate of Aspergillus identification among participants with CD4 counts Conclusions Although Aspergillus is infrequently isolated from HIV-infected persons, the associated high mortality would support serious consideration of its clinical significance in those with advanced disease and risk factors. |
| Databáze: | OpenAIRE |
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