Design of etoposide polymeric forms
| Autor: | E. A. Vorontsov, Yu. P. Semochkina, S. L. Kuznetsov, N. V. Gukasova, A. I. Murav’eva, E. Yu. Moskaleva, I. A. Tubasheva, S. E. Severin, G. A. Posypanova, Vasilisa V. Zavarzina |
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| Rok vydání: | 2016 |
| Předmět: |
Drug
Materials science media_common.quotation_subject macromolecular substances 02 engineering and technology Pharmacology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pulmonary surfactant Cryoprotective Agent medicine General Materials Science Etoposide media_common chemistry.chemical_classification technology industry and agriculture General Engineering Polymer 021001 nanoscience & nanotechnology Condensed Matter Physics Combinatorial chemistry In vitro PLGA chemistry Cell culture 030220 oncology & carcinogenesis 0210 nano-technology medicine.drug |
| Zdroj: | Nanotechnologies in Russia. 11:247-255 |
| ISSN: | 1995-0799 1995-0780 |
| Popis: | The present work relates to the field of pharmacology and medicine, in particular, to a new generation of anticancer drugs based on biocompatible polymers containing etoposide as the drug substance. A polymeric composition containing a surfactant and cryoprotective agent in addition to polymer and drug substance was designed. The optimum formulation of the polymeric composition and process conditions for its preparation were selected. The samples of etoposide polymeric forms were found to exhibit in vitro cytotoxic activity against two human tumor cell lines, viz., MCF-7 breast adenocarcinoma and K562 myeloleukemia cell lines, which was either identical or higher than the activity of free etoposide. The samples of the PLGA-based polymeric form of etoposide exhibited the highest activity. |
| Databáze: | OpenAIRE |
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