Reelin expression in liver and pancreas and its correlation with liver fibrosis
| Autor: | Francesconi, Maria, Carotti, Simone, Amato, Michelina, Vespasiani-Gentilucci, Umberto, Picardi, Antonio, Perrone, Giuseppe, Morini, Sergio |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| DOI: | 10.13128/ijae-21815 |
| Popis: | Reelin is an extracellular glycoprotein secreted by a variety of cell types in both embryonic and adult tissue and plays a critical role during brain development (1,2). Reelin is up-regulated in experimental liver cirrhosis of rats in hepatic stellate cell(HSC)s, the cell type mainly implicated in liver fibrogenesis, supporting that reelin is involved in the pathogenesis of liver fibrosis (3). Pancreatic stellate cell(PSC)s share similar morphology and function to HSCs, in pancreatic fibrosis setting (4). Currently, the role of reelin in human liver and pancreas is still unclear. We investigated reelin expression in different stages of chronic liver disease in 81 liver biopsies of HCV affected patients and in pancreatic tissue near to tumoral lesions. The expression of Reelin, HSC markers (CRBP1, alpha-SMA) and Dab1, a Reelin adaptor protein, was investigated by immunohistochemistry and immunofluorescence. Reelin protein was expressed by HSCs and a strong correlation was found between Reelin expression and liver fibrosis stage (p Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016 |
| Databáze: | OpenAIRE |
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