Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone
| Autor: | Pelin Pelit Arayici, Serap Derman, Zeynep Mustafaeva, N. Buyuk, Sevil Yücel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin Scanning electron microscope Sonication technology industry and agriculture Nanoparticle macromolecular substances 030226 pharmacology & pharmacy Controlled release Chitosan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Differential scanning calorimetry chemistry Drug delivery Nuclear chemistry |
| Zdroj: | Indian Journal of Pharmaceutical Sciences. 82 |
| Popis: | This work is based on a natural polymer chitosan used in a nanoparticulate drug delivery system for the controlled release of amiodarone along with β-cyclodextrin. Amiodarone-loaded chitosan nanoparticles were prepared using the ionic gelation method aided by sonication. Amiodarone loading on chitosan nanoparticles was done under optimum conditions. For particle characterization; zeta-sizer, UV/Vis, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimeter and scanning electron microscope techniques were used. In vitro drug release studies of amiodaroneloaded chitosan nanoparticles were performed using the dialysis diffusion technique. Drug loading and release values were determined using UV/Vis spectroscopy. Amiodarone encapsulated in nanoparticles was completely released at the end of 14 days. About 38 % was released at the end of day 1, 44% released at the end of day 3, 50 % released at the end of day 5 followed slow release. Amiodarone-loaded chitosan nanoparticles could serve as a model for controlled delivery of many antiarrhythmic drugs. |
| Databáze: | OpenAIRE |
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