| Autor: |
H. S. Khalil, S. I. Sa'sa', I. M. Jalal |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Journal of Liquid Chromatography. 9:3617-3631 |
| ISSN: |
0148-3919 |
| Popis: |
Despite the availability of several commercial suspension formulations of metronidazole benzoate, there is no official method for its analysis. The conventional analytical method requires extensive extraction following each extraction with evaporation then non-aqueous titration with perchloric acid. The method is time-consuming and is not stability-indicating. This proposed HPLC methodology has the advantages of being fast since it requires no chemical manipulation. The assay is stability-indicating being capable of separating the hydrolysis products (metronidazole and benzoic acid) and the common impurity (2-methyl-5-nitroimidazole) from metronidazole benzoate. The method is also specific as it is free of interferences from excipients. The proposed HPLC method was verified for linearity, accuracy and precision and was applied successfully to several commercial suspensions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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