Prognostic Implications of Left Ventricular Global Peak Systolic Longitudinal Strain in Lymphoma Patients Undergoing Anti-Cancer Therapy

Autor:	Tsai Yun Chen, Ping Yen Liu, Ya-Ping Chen, Po-Lan Su, Chun-Hui Lee, Wei-Chuan Tsai, Ming-Yueh Chen, Sin Syue Li, Ya-Ting Hsu, Hsien-Yuan Chang, Yen-Wen Liu
Rok vydání:	2020
Předmět:	Chemotherapy medicine.medical_specialty business.industry medicine.medical_treatment Incidence (epidemiology) Hazard ratio Cancer medicine.disease Confidence interval Informed consent Heart failure Internal medicine medicine Cardiology business Subclinical infection
Zdroj:	SSRN Electronic Journal.
ISSN:	1556-5068 1070-3039
DOI:	10.2139/ssrn.3551374
Popis:	Background: Left ventricular (LV) global peak systolic longitudinal strain (GLS) detected by speckle-tracking echocardiography is a sensitive modality for detecting subclinical LV systolic dysfunction and a powerful prognostic predictor. However, the clinical implication of LV GLS in lymphoma patients receiving anti-cancer therapy remains unknown. Methods: We prospectively enrolled 74 lymphoma patients (57.9±17.0 years old, 57% male patients) having echocardiographic study before chemotherapy, after the 3 rd and 6 th chemotherapy cycles and 1 year after chemotherapy. A ≥15% reduction in absolute GLS value from baseline was defined as signifying cancer therapy–related cardiac dysfunction (CTRCD). After completing three cycles of anticancer therapy, cardiopulmonary exercise testing (CPET) was conducted. The primary outcome was defined as a composite of heart failure events and all-cause mortality. Findings: In 36 (49%) patients with CTRCD, LV GLS significantly decreased after the 3 rd cycle of chemotherapy (20.1±2.6% vs . 17.5±2.3%, p
Databáze:	OpenAIRE
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