| Autor: |
Hye Jin Kim, Yong Sup Lee, Dong Woon Kim, Kilwoong Mo, Sang Hoon Park, Young Hun Lee, Hyoung Ja Kim, Seunghwan Kim, Nam-Jung Kim, Changbae Jin |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Bulletin of the Korean Chemical Society. 36:1335-1339 |
| ISSN: |
1229-5949 |
| DOI: |
10.1002/bkcs.10253 |
| Popis: |
Recently, many reports revealed that there are close correlations between antioxidant and anticancer activities of compounds. In this study, we designed 4-hydroxy-3′,4′-dihydroxychalcone (2) as a ring-opened analog of luteolin, which has been known to possess both antioxidant and anticancer activities, and then introduced aminoethyl moieties to this chalcone structure to increase water solubility by transforming into HCl salts. Synthesized aminoalkyl-substituted chalcones 3a–3d showed potent antioxidant activities in three different assay systems and anticancer activities against four tumor cell lines tested. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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