Long-Term High-Titer Neutralizing Activity Induced by Octameric Synthetic HIV-1 Antigen

Autor:	David Looney, Barbara Hosein, Alan M. Walfield, James P. Tam, M.-L. Li, Flossie Wong-Staal, J Ye, Chang Yi Wang
Rok vydání:	1991
Předmět:	chemistry.chemical_classification Multidisciplinary Immunogenicity Peptide Biology Virology Neutralization Titer HIV Antigens chemistry biology.protein Antibody Bovine serum albumin Peptide sequence
Zdroj:	Science. 254:285-288
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1925584
Popis:	A titer for homologous viral neutralization activity (greater than 1:19,683) was observed after a 3.5-year immunization period with an octameric, branching peptide representing the principal neutralizing determinant (PND) of the human immunodeficiency virus-1IIIB envelope protein. Booster immunizations elicited persistent and potent antibodies in guinea pigs, exceeding responses produced by a conventional bovine serum albumin conjugate by 100-fold. Peptide length, central presentation of a conserved sequence, and inclusion of an upstream sequence contributed to immunogenicity. Titers (greater than 1:1,000) of heterotypic neutralizing antibodies also developed. Octameric PND peptides are a promising approach for an acquired immunodeficiency syndrome (AIDS) vaccine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3769a97d6561a0c8f73b1bea336bca1b https://doi.org/10.1126/science.1925584 Zobrazit plný text záznamu Plný text ve formátu PDF