Effects of risk factors in the likelihood of breast cancer subtypes in Brazilian women
| Autor: | Kleber Morais de Sousa, Sinara Mônica Vitalino de Almeida, Felipe de Melo Souza, Solange Maria da Silva |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | ABCS Health Sciences. 46 |
| ISSN: | 2357-8114 2318-4965 |
| DOI: | 10.7322/abcshs.2020057.1505 |
| Popis: | Introduction: Breast cancer is a heterogenous disease with multiple causes and it lacks more investigation related to its risk factors. Objective: To evaluate the likelihood of breast cancer subtypes according to the positivity to estrogen and progesterone receptors (ER+ and PR+ respectively), with or without the expression HER2, related to the following risk factors: age, parity, diabetes mellitus, arterial hypertension, occurrence of familiar cancer case and body mass index (BMI). Methods: The sample with 79 individuals was divided into three subtypes 1 (ER+/PR-), 2 (ER+/PR+) and 3 (RE+/RP+/HER+) and then analyzed by quantitative methods using Ordinal Generalized Linear Models (OGLM) for estimating the marginal effects of risk factors for the studied subtypes, and modeling the heteroscedasticity in terms of error. Results: It were observed the following statistically significant positive effects: (1) age for the tumoral subtype 1 (ER+/PR-) and (2) parity for the subtype 2 (ER+/PR+); while the significant negative effects were: (1) age for subtype 3 (ER+/PR+/HER2+); (2) parity for both 1 (ER+/PR-) and 3 (ER+/PR+/HER2+) subtypes; and arterial hypertension for subtype 1 (ER+/PR-). There were no statistically significant effects for BMI, Diabetes mellitus and occurrence of familiar cancer variables on the studied tumoral subtypes. Conclusion: The risk factos age and parity demonstrated varied effects for the breast cancer subtypes according the expression of estrogen, progesterone and HER2 receptors. |
| Databáze: | OpenAIRE |
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