On-Surface Cyclization of Tetrapeptides Using Molecularly Imprinted Polymers as Non-Covalent Auxiliaries
| Autor: | Kao-Haw Lu, Chi-Tai Chen, Yee-Fung Lin, Dar-Fu Tai, Shih-Ming Lee |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Tetrapeptide Non covalent technology industry and agriculture Molecularly imprinted polymer Peptide General Chemistry Combinatorial chemistry Hydrophobic effect chemistry.chemical_compound Molecular recognition Robotic systems chemistry heterocyclic compounds Cellulose |
| Zdroj: | Journal of the Chinese Chemical Society. 56:127-134 |
| ISSN: | 0009-4536 |
| DOI: | 10.1002/jccs.200900018 |
| Popis: | Based on the fabrication of molecularly imprinted polymeric film on cellulose paper (MIFC), we have developed a robotic system for homodetic tetrapeptide cyclization. We constructed molecularly imprinted polymeric film (MIPF) on cellulose paper as the non-covalent auxiliary to assist cyclic tetrapeptide (CTP) formation. Tetrapeptides were bound by their hydrophobic interaction with MIFC. With the help of MIFC and a coupling reagent, quantitative synthesis of CTPs was achieved conveniently for various tetrapeptides. The syntheses of cyclic tetrapeptide (CTP) could also be facilitated using the MIFC induced from CTP or other tetrapeptides with partially matched sequences. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text