Synthesis of[3,5-dichlorobenzenesulfonamide-U-14C)] labeled VLA-4 antagonists

Autor:	Conrad E. Raab, David G. Melillo, Linus S. Lin, Dennis C. Dean, Nathan X. Yu
Rok vydání:	2004
Předmět:	Chemistry Stereochemistry Organic Chemistry Drug Discovery Benzene derivatives Radiology Nuclear Medicine and imaging Biochemistry Chemical synthesis Spectroscopy Analytical Chemistry
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 47:115-125
ISSN:	1099-1344 0362-4803
DOI:	10.1002/jlcr.804
Popis:	Radiolabeled tracers were required for the development of a series of VLA-4 antagonists. A method to synthesize [U-14C]3,5-dichlorobenzenesulfonyl chloride was developed. From this key intermediate, various tracers were prepared in high yield. Copyright © 2004 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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