In VivoEffects of Steroid Hormones on the Testosterone 5α-Reductase in Rat Skin
| Autor: | Roland R. Tremblay, Ngoc-Ha Ngo-Thi, Jean Dubé |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
integumentary system medicine.drug_class Adrenalectomy medicine.medical_treatment Biology chemistry.chemical_compound Steroid hormone Endocrinology Castration chemistry Corticosterone Estrogen Internal medicine Dihydrotestosterone medicine Testosterone Hormone medicine.drug |
| Zdroj: | Endocrinology. 97:211-214 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-97-1-211 |
| Popis: | We have studied the hormonal regulation of the levels of testosterone 5α-reductase in rat skin by performing surgical manipulations (gonadectomy and/or adrenalectomy) of the rats and by steroid administration to ovariectomizedadrenalectomized rats. Castration significantly increases (P < 0.01) the enzyme activity in the sole of the foot but not in the thoracic skin of male rats. In female rats, significant elevations of the enzyme activity are observed in the thoracic skin (P < 0.01)and in the sole of the foot (P α 0.05) after ovariectomy. Estrogen administration decreases the enzyme activity in thoracic skin, tail skin and vulvar skin of ovariectomized-adrenalectomized rats. Testosterone and dihydrotestosterone decrease the activity in the sole of the foot and increase the activity in vulvar skin. Progesterone and corticosterone administration produce no significant effects in the four skin types studied (Endocrinology 97: 211, 1975) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|