Conjugates of Hepatitis B Surface Antigen (14-32)Pre-S2 Region with N-Acetylmuramic Acid, N-Acetylnormuramic Acid, and Their L-Alanyl-D-Isoglutamine Derivatives: Synthesis and Studies on Immunogenicity

Autor:	Zbigniev Maćkiewicz, Maria Kalmanowa, Hanna Świderska, Gotfryd Kupryszewski, Adam Nowosławski, Zygfryd Smiatacz
Rok vydání:	1992
Předmět:	Isoglutamine HBsAg biology Chemistry Immunogenicity General Chemistry biology.organism_classification chemistry.chemical_compound Antigen Hepadnaviridae Biochemistry N-Acetylmuramic acid Humoral immunity biology.protein bacteria Antibody
Zdroj:	Collection of Czechoslovak Chemical Communications. 57:204-211
ISSN:	1212-6950 0010-0765
Popis:	Four novel analogs of hepatitis B virus surface antigen (14-32)Pre-S2 region fragment attached covalently to N-acetylmuramic acid, N-acetylmuramyl-L-alanyl-D-isoglutamine, N-acetylnormuramic acid, and N-acetylnormuramyl-L-alanyl-D-isoglutamine were synthesized by the solid phase method. The ability of analogs to induce cellular and humoral immunity to native HBsAg was tested on rabbits. Cellular immune response occurred in vitro, and HBs antibodies were detected in all immunized animals. No additional adjuvants were used in the tests.
Databáze:	OpenAIRE
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