708 Percutaneous Coronary Intervention Improves Outcomes in Patients with Coronary Artery Disease Undergoing Lung Transplantation
| Autor: | A.D. Perulakar, Scott Scheinin, Brian A. Bruckner, S. La Francesca, Harish Seethamraju, W. Fischer, Jerry D. Estep, T. Motomura, R.R. Bunge, Matthias Loebe |
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| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transplantation medicine.medical_specialty business.industry medicine.medical_treatment Confounding Percutaneous coronary intervention medicine.disease Logistic regression Coronary artery disease Internal medicine Pulmonary fibrosis Cardiology Medicine Lung transplantation Surgery Cardiology and Cardiovascular Medicine business Lung allocation score |
| Zdroj: | The Journal of Heart and Lung Transplantation. 31:S243 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2012.01.723 |
| Popis: | plant database. Descriptive statistics were used. We analyzed time to event using Kaplan-Meier, groups were compared using the log-rank test. Logistic regression was used to adjust for potential confounders. P-values of 0.05 were considered statistically significant. Results: Fifty-four percent (n 184) of patients listed for transplant were male and 46% (n 156) were female. Median age at listing was 59.5 years old. Distribution of diagnoses was 45% pulmonary fibrosis, 25% chronic obstructive pulmonary disease, 11% cystic fibrosis, 4% pulmonary arterial hypertension, and 9% other. Median lung allocation score (LAS) at listing was 37.8. Of the 340 patients, 37 (11%) had a PRA 25%. Likelihood of transplant was lower in patients with PRA 25% (51% vs. 84%, p 0.001). Median time to transplant was longer in patients with PRA 25% (186 days versus 46 days, p 0.001). Death on the waitlist was also significantly higher in the allosensitized group (19% versus 7%, p 0.01) compared to the non-allosenzited group. Multivariable analysis demonstrated that patients with PRA 25% were at increased risk of death on the waiting list (OR 5.12; 95% CI: 1.79-14.63, p 0.004), after adjusting for LAS and age. Conclusions: In our study, PRA 25% was associated with a lower likelihood of transplantation, longer time to transplant, and increased risk of dying on the waiting list. Given these findings, further studies evaluating the effects of desensitization are warranted. |
| Databáze: | OpenAIRE |
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