EFFECT OF AMINO ACID ON THE DEVELOPMENT SKIN TISSUE ORGANOTYPIC CULTURE

Autor:	Natal'ya I Chalisova, Aleksander E Korovin
Rok vydání:	2017
Předmět:	Glutamine chemistry.chemical_classification Tissue culture integumentary system chemistry Biochemistry Arginine Radical Cyclophosphane Lysine Amino acid Explant culture
Zdroj:	Bulletin of the Russian Military Medical Academy. 19:71-76
ISSN:	2687-1424 1682-7392
Popis:	The effect of the 20 coded amino acids was investigated on the development of the processes of the proliferation in the organotypic tissue culture of rat skin. The amino acids lysine, arginine and glutamine acid at 0,05 ng/ml concentration stimulated the cellular proliferation in the growth zone of explants by 29-30%. The mustard-like agent cyclophosphane at 1 mg/ml concentration inhibited the cellular proliferation. The delay of this inhibiting effect of cyclophosphane was observed by the combined action of stimulating amino acids with the cyclophosphane. Thus, the amino acids with the charge radicals can be protectors of the cellular proliferation by the toxic effect of the cyclophosphane on the skin. This effect can be used for the treatment of the mustard injury of skin and for the delay of the adverse effect of cytostatic in oncology (1 figure, 1 table, bibliography: 28 refs).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::371669d6938878851837085f9ea0b429 https://doi.org/10.17816/brmma12192 Zobrazit plný text záznamu