Effects of combined Pulsed Dye Laser and Fractional CO2 Laser treatment of burn scars and correlation with plasma levels of collagen type I, MMP-2 and TIMP-1
| Autor: | Wojciech Dębek, Olga M. Koper-Lenkiewicz, Joanna Kamińska, Adam Hermanowicz, Ewa Matuszczak, Artur Weremijewicz, Marta Komarowska, Marzena Tylicka |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Dye laser Co2 laser business.industry Urology Scars 030208 emergency & critical care medicine General Medicine Plasma levels Matrix metalloproteinase Critical Care and Intensive Care Medicine medicine.disease 030207 dermatology & venereal diseases 03 medical and health sciences Inguinal hernia 0302 clinical medicine Emergency Medicine medicine Surgery medicine.symptom business Type I collagen Burn scar |
| Zdroj: | Burns. 47:1342-1351 |
| ISSN: | 0305-4179 |
| DOI: | 10.1016/j.burns.2020.12.011 |
| Popis: | Hypertrophic burn scars remain a significant burden for patients and a challenge for clinicians. The aim Assessement of the efficacy of combined Pulsed Dye Laser and Ablative Fractional CO2 Laser therapy on hyperthophic scars and correlation with plasma levels of MMP-2, TIMP-1 and alpha-1 type I collagen. Patients and methods Twenty five pediatric subjects were enrolled into the study. Control group consisted of age-matched subjects admitted for surgical repair of inguinal hernia. For the assessment of the results of laser treatment we used the Vancouver scar scale (VSS), and Patient-Observer Scar Assessment Scale (POSAS). We also correlated clinical results with plasma levels of MMP-2, TIMP-1 and alpha-1 type I collagen. Results All subjects reported the laser treatment resulted in improvement and were somewhat satisfied or very satisfied with their experience. No adverse events were reported. The levels of MMP-2, TIMP-1 and alpha-1 type I collagen in our patients with scars before laser threatment were higher in comparison to controls. We also found statistically significant decrease in the levels of MMP-2, TIMP-1 and alpha-1 type I collagen after laser treatment of burn scars Conclusions Our study clearly shows that combined CO2-AFL treatment for burn scars improve texture, colour, function and alleviate pruritus. We believe that decrease in the levels of MMP-2, TIMP-1 and alpha-1 type I collagen after laser treatment of burn scars, reflects reduced dynamic of scar. |
| Databáze: | OpenAIRE |
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