A partially blinded randomised controlled trial of patient-maintained propofol sedation and operator controlled midazolam sedation in third molar extractions

Autor:	K. J. Anderson, Keith Millar, S. Gambhir, J. A. Leitch, Gavin N. C. Kenny, S. McHugh, Nigel D. Robb
Rok vydání:	2004
Předmět:	Psychomotor function medicine.medical_specialty business.industry Sedation Amnesia Surgery law.invention Anesthesiology and Pain Medicine Randomized controlled trial law Anesthesia Dental surgery Heart rate medicine Midazolam medicine.symptom business Propofol medicine.drug
Zdroj:	Anaesthesia. 59:853-860
ISSN:	1365-2044 0003-2409
Popis:	Summary Patient-maintained sedation using propofol has recently been shown to be effective for dental surgery. We compared this new technique to the established technique of operator administered midazolam. The two groups were compared before, during and after sedation. The two primary outcomes were time until discharge and oxygen saturation. Vital signs, anxiety and psychomotor skills were also compared. State anxiety was reduced to a greater extent in the propofol group (mean difference 10 (SD 4) mm; p = 0.010. Propofol patients recovered quicker (mean difference 7 (SD 1.4) min; p = 0.001). Propofol patients had a smaller reduction in arterial oxygen saturation (mean difference 0.8 (SD 0.3)%; p = 0.030), and a reduced increase in heart rate (mean difference 9 (SD 2) beats.min –1 ; p < 0.001). Both techniques were well tolerated and safe. Propofol sedation offered superior anxiolysis, quicker recovery, less amnesia and less depression of simple psychomotor function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3705391e0d108b3aa0c7b140bef2fd6e https://doi.org/10.1111/j.1365-2044.2004.03761.x Zobrazit plný text záznamu Plný text