Characterization of a Novel Acidic Polysaccharide with Immunological Activities from the Rhizome of Cnidium officinale

Autor:	Noriko Shimizu, Ryoko Gonda, Naoko Ohara, Masashi Tomoda
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Molecular mass Biological activity General Chemistry General Medicine Uronic acid Pharmacognosy Polysaccharide In vitro Rhizome Gel permeation chromatography chemistry.chemical_compound Biochemistry chemistry Drug Discovery
Zdroj:	Chemical and Pharmaceutical Bulletin. 42:1886-1889
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.42.1886
Popis:	An acidic polysaccharide, called cnidirhan SIIB, was isolated from the rhizome of Cnidium officinale MAKINO. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.9×104. It was composed of L-arabinose, D-galactose and D-galacturonic acid in the molar ratio of 9 : 11 : 3, in addition to a few O-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation studies indicated that its structural features are composed primarily of α-L-arabino-β-3, 6- and 3, 4-branched D-galactan type units. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test and marked anti-complementary activity.
Databáze:	OpenAIRE
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