Amygdala DCX and blood Cdk14 are implicated as cross-species indicators of individual differences in fear, extinction, and resilience to trauma exposure
| Autor: | Rick Richardson, Adriana Lori, Kerry J. Ressler, Vasiliki Michopoulos, Stephanie A. Maddox, Marissa Maheu, G King, Aliza P. Wingo, Sumeet Sharma |
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| Rok vydání: | 2021 |
| Předmět: |
Trauma response
medicine.medical_specialty biology business.industry Neurogenesis Wnt signaling pathway Classical conditioning Extinction (psychology) Amygdala Doublecortin Cellular and Molecular Neuroscience Psychiatry and Mental health Endocrinology medicine.anatomical_structure Internal medicine biology.protein Medicine Fear learning business Molecular Biology |
| Zdroj: | Molecular Psychiatry. 27:956-966 |
| ISSN: | 1476-5578 1359-4184 |
| Popis: | Doublecortin (DCX) has long been implicated in, and employed as a marker for, neurogenesis, yet little is known about its function in non-neurogenic brain regions, including the amygdala. This study sought first to explore, in rodents, whether fear learning and extinction modulate amygdala DCX expression and, second, to assess the utility of peripheral DCX correlates as predictive biomarkers of trauma response in rodents and humans. Pavlovian conditioning was found to alter DCX protein levels in mice 24 h later, resulting in higher DCX expression associated with enhanced learning in paradigms examining both the acquisition and extinction of fear (p |
| Databáze: | OpenAIRE |
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