In vivo formation of Cu(DDC)2 complex induced by nanomedicine for mesothelioma chemotherapy
| Autor: | Xinyu Peng, Jing Chang, Wenxia Gao, Yixin Zhang, Junhua Li, Bin He, Jing Li, Shunjie Ding |
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| Rok vydání: | 2020 |
| Předmět: |
Copper gluconate
integumentary system medicine.medical_treatment Intraperitoneal injection chemistry.chemical_element 02 engineering and technology General Chemistry Pharmacology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Copper 0104 chemical sciences PLGA chemistry.chemical_compound chemistry In vivo Cancer cell Disulfiram medicine Nanomedicine 0210 nano-technology medicine.drug |
| Zdroj: | Chinese Chemical Letters. 31:3168-3172 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2020.04.051 |
| Popis: | The copper(II) diethyldithiocarbamate (Cu(DDC)2) complex exhibited excellent inhibition to cancer cells. The usual administration is intravenous injection for disulfram and oral for copper. A new strategy was reported to improve the administration efficiency of the Cu(DDC)2 drug. Poly(lactide-co-glycolide) (PLGA) nanoparticles were used to trap disulfram and copper gluconate separately, the two types of drug loaded nanoparticles were injected in mesothelioma-bearing nude mice via intraperitoneal injection. The in vivo formation of Cu(DDC)2 complex was induced by disulfiram and Cu2+ released from PLGA nanoparticles. This strategy avoided many obstacles in the use of Cu(DDC)2 complex as chemotherapeutic and exhibited excellent anticancer activity to mesothelioma. |
| Databáze: | OpenAIRE |
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