Changes in plasma high density lipoproteins and lipolytic enzymes after long-term, heavy ethanol consumption
| Autor: | Göran Fex, J. Wadstein, Peter Nilsson-Ehle, R. Ekman, Bengt G. Johansson |
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| Rok vydání: | 1981 |
| Předmět: |
Intermediate-density lipoprotein
Very low-density lipoprotein medicine.medical_specialty Lipoprotein lipase Clinical Biochemistry Reverse cholesterol transport General Medicine chemistry.chemical_compound High-density lipoprotein Endocrinology chemistry Biochemistry Internal medicine Low-density lipoprotein medicine lipids (amino acids peptides and proteins) Hepatic lipase Lipoprotein |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 41:709-715 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365518109090519 |
| Popis: | Plasma high density lipoprotein (HDL) concentrations are often increased in chronic alcoholism. The mechanism for this hyperalphalipoproteinaemia was investigated in seven male chronic alcoholics. Determinations of lipoprotein lipase, hepatic lipase and lecithin-cholesterol acyl trailsferase activities and of lipid concentrations in plasma and lipoproteins were made immediately after a debauch and during an abstinence period of 10 days. The lipoprotein patterns registered immediately after cessation of ethanol intake were characterized by elevated concentrations of HDL, especially the HDL2 subclass. Postheparin plasma lipoprotein lipase activities were also increased. During the observation period HDL levels and lipoprotein lipase activities decreased by about 40%. Concomitantly there was a small but significant increase in the concentrations of plasma and very low density lipoprotein (VLDL) triacylglycerol, and of plasma and low density lipoprotein (LDL) cholesterol concentrations. The results suggest th... |
| Databáze: | OpenAIRE |
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