Alcohol use in adolescence, impulsivity, and risk-taking behavior in Wistar rats
| Autor: | Letícia Scheidt, Rosa Maria Martins de Almeida, Charles Francisco Ferreira, Augusto Viana Pires, Carolina Gubert, Jonatas Argemi Foster Passos, Lisiane Bizarro, Luis Alexandre de Almeida |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Elevated plus maze Ethanol General Neuroscience Physiology Alcohol abuse Alcohol medicine.disease Impulsivity chemistry.chemical_compound Route of administration Neuropsychology and Physiological Psychology chemistry medicine Anxiety medicine.symptom Psychology Psychiatry Risk taking |
| Zdroj: | Psychology & Neuroscience. 8:130-142 |
| ISSN: | 1983-3288 1984-3054 |
| DOI: | 10.1037/h0101023 |
| Popis: | Adolescence is an important neurodevelopmental stage for brain sites that are related to the impulse control and reward systems. Alcohol abuse during this period may cause irreversible modifications of neural circuits that are linked to impulsivity. The present study evaluated the effects of alcohol ingestion during adolescence in Wistar rats on anxiety, risk-taking, and impulsive behavior parameters during adulthood. Male Wistar rats (n 40) were randomly assigned to 1 of 3 treatments: 0, 1, and 3 g/kg alcohol administered orally over 9 sessions, from postnatal Day 31 to 50. Anxiety and risk-taking behaviors were assessed in the elevated plus maze soon after adolescence and during adulthood, and impulsivity was assessed in the operant delay-discounting task in adulthood. None of the alcohol treatments altered risk-taking or impulsive behavior compared with the control group. The group that received 3 g/kg alcohol exhibited less anxiety-like behavior in the first exposure to the elevated plus maze compared with the control group. The results are discussed with regard to the doseresponse, frequency, duration, and age of exposure and route of administration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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