Pharmacologically interesting compounds—I: High resolution mass spectra of phenothiazines

Autor:	Brian J. Millard, J. N. T. Gilbert
Rok vydání:	1969
Předmět:	Stereochemistry Substituent chemistry.chemical_element High resolution Biochemistry Nitrogen Medicinal chemistry Ion chemistry.chemical_compound chemistry Fragmentation (mass spectrometry) Phenothiazine Mass spectrum Side chain Molecular Medicine Instrumentation Spectroscopy
Zdroj:	Organic Mass Spectrometry. 2:17-31
ISSN:	1096-9888 0030-493X
DOI:	10.1002/oms.1210020103
Popis:	The mass spectra of twenty-six commercially available medicinal phenothiazines have been determined at high resolution. In each compound, the side chain attached to the 10-position of the phenothiazine ring contains nitrogen and fission of the CC bond α to this nitrogen gives in most cases the base peak. Some of the compounds are also substituted at the 2-position and this substituent generally remains intact, though some substituents such as acetyl, propionyl, methoxyl and methylthio can undergo fragmentation. Fragmentations fall into three groups; those which give ions representing a part of the side chain; those which give ions representing the intact phenothiazine ring with part of the side chain attached; those which give ions representing a partially fragmented ring system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::36efcc1715bdc05c128ffebd3ade4be8 https://doi.org/10.1002/oms.1210020103 Zobrazit plný text záznamu Plný text