Effect of cloned human interferon-? 2a on bovine parainfluenza-3 virus

Autor:	S. B. Mohanty, R. M. Friedman, R. K. Maheshwari, P. Panigrahi
Rok vydání:	1988
Předmět:	chemistry.chemical_classification Paramyxoviridae biology viruses Alpha interferon General Medicine biology.organism_classification Virology Molecular biology Virus Viral replication chemistry Interferon medicine Glycoprotein Interferon type I Interferon alfa medicine.drug
Zdroj:	Archives of Virology. 98:107-115
ISSN:	1432-8798 0304-8608
DOI:	10.1007/bf01321011
Popis:	Pretreatment of bovine turbinate (BTu) cells with cloned human interferon (IFN)-α 2a reduced the yield of infectious bovine parainfluenza-3 virus (PI-3V). Intracellular synthesis of HN glycoprotein was reduced on postinfection day 1 (PID 1), but it recovered to normal levels subsequently. However, reduction of this protein persisted in the released virus through PID2. Thin section electron microscopy demonstrated a drastically reduced release of mature virions and an accumulation of viral nucleocapsids inside the cytoplasm on PID2. These results suggest that cloned human IFN-α 2a affects the glycoprotein synthesis, and morphogenesis of bovine PI-3V, and thus inhibits the release of viral particles from treated cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::36e498857cc450dac404ba19d97db3af https://doi.org/10.1007/bf01321011 Zobrazit plný text záznamu Full text from SpringerLink