Melanoma Recurrence after Negative Sentinel Lymph Node Biopsy

Autor:	Jeffrey N. Myers, Ryan Patrick Goepfert, Melinda Davis-Malesevich
Rok vydání:	2011
Předmět:	medicine.medical_specialty medicine.diagnostic_test business.industry Melanoma Nodal metastasis Sentinel lymph node medicine.disease Surgery Breslow Thickness Otorhinolaryngology Biopsy Cutaneous melanoma medicine Referral center Head and neck business
Zdroj:	Otolaryngology–Head and Neck Surgery. 145
ISSN:	1097-6817 0194-5998
DOI:	10.1177/0194599811416318a94
Popis:	Objective: Delineate clinico-pathologic factors associated with recurrence of cutaneous melanoma of the head and neck region and survival after negative sentinel lymph node biopsy (SLNB).Method: A retrospective review from January 2000 to June 2009 was conducted at a tertiary referral center. Characteristics and outcomes of 204 patients with head and neck melanoma who underwent negative SLNB were analyzed in a univariant and multivariant fashion. Main outcomes measured included: local, regional, distant recurrences, and survival.Results: A total of 204 patients with cutaneous melanoma of the head and neck underwent successful SLNB, in which final pathology was negative for nodal metastasis. Fifty-nine recurrences occurred in 42 patients: local/in-transit 18, regional 17, and distant metastasis 24. Five recurrences occurred within the same nodal basin that harbored the negative SLN(s). Decreased survival was associated with Breslow thickness (P < .05) and ulceration (P < .006). Local recurrence was associa...
Databáze:	OpenAIRE
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