Efficacy of Urea Therapy in Children with Ichthyosis
| Autor: | S. Groll, W. Küster, K. Bohnsack, H. Traupe, H.-J. Upmeyer, F. Rippke |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
integumentary system business.industry Ichthyosis Hyperkeratosis Treatment outcome Follow up studies Dermatology medicine.disease eye diseases Dyskeratosis Multicenter study parasitic diseases otorhinolaryngologic diseases medicine Itching medicine.symptom Pediatric dermatology skin and connective tissue diseases business |
| Zdroj: | Dermatology. 196:217-222 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000017902 |
| Popis: | Background: Ichthyoses are genetic disorders of keratinization which are uncomfortable due to their conspicuous scaling, itching and cosmetic problems. Especially in childhood, ichthyoses can lead to social discrimination and psychological problems. Efficient therapies are necessary which are safe and well tolerated. Objective: The aim of the study was to investigate the keratolytic and moisterurizing properties as well as the tolerance of a new urea lotion when applied to hyperkeratotic and ichthyotic skin in childhood. Methods: The study was conducted as a multicenter, randomized, placebo-controlled, double-blind, semilateral investigation. Sixty children between 1 and 16 years treated one side of the most affected extremity with Laceran 10% urea lotion for 8 weeks. On the other side the urea-free Laceran lotion base was given. On each side of the body a control area was left untreated. The investigators evaluated the global severity of ichthyotic symptoms with the help of a visual analogue scale. Results: The analysis of the global estimation of severity of ichthyosis showed improvements being stronger in the body areas treated with Laceran 10% urea lotion (from 4.8 to 2.0 points) than in the areas treated with the urea-free Laceran lotion base (from 4.8 to 2.5 points). The response rates were 65% after 4 weeks and 78% after 8 weeks for Laceran 10% urea lotion, 50% after 4 weeks and 72% after 8 weeks for the urea-free Laceran lotion base. Conclusion: It can be ascertained that Laceran 10% urea lotion has a strong positive effect on generalized ichthyotic keratinization disorders. |
| Databáze: | OpenAIRE |
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