Pheochromocytoma
| Autor: | Galindo Lm, Vinod B. Shidham |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Histology medicine.diagnostic_test business.industry General Medicine Neuroendocrine tumors medicine.disease Pathology and Forensic Medicine Ganglion Pheochromocytoma Fine-needle aspiration medicine.anatomical_structure Cytopathology Salt-and-pepper chromatin Cytology Medicine business Hyaline |
| Zdroj: | Acta Cytologica. 43:207-213 |
| ISSN: | 1938-2650 0001-5547 |
| DOI: | 10.1159/000330978 |
| Popis: | BACKGROUND: There have been few studies describing the cytology of adrenal pheochromocytoma (PC). Although fine needle aspiration (FNA) for a preoperative diagnosis of PC is generally considered a contraindication, this tumor can be an unsuspected finding in adrenal FNA performed for other reasons. STUDY DESIGN: Scrape cytology smears prepared in five cases of PC were examined for different cytomorphologic features. The results were correlated with the corresponding permanent histologic sections. RESULTS: Previously described features, like cellular smears showing cells with abundant, poorly defined fragile cytoplasm, bare nuclei, anisonucleosis, salt and pepper chromatin, variable nucleoli and few ganglion cell-like cells, were noted. In addition, several previously unreported cytologic features were observed: (1) loosely cohesive PC cells along a ramifying, delicate central core ; (2) intracytoplasmic microvesicular (not hyaline/homogeneous) globules; and (3) different arrangements of capillary-stroma and PC cells (Zellballen pattern; empty capillary rings; stroma with adherent, intact PC cells or fragments of disrupted PC cell cytoplasm). CONCLUSION: The cytologic appearance of PC may resemble that of other neuroendocrine tumors; however, it can be diagnostic when combined with proper clinical data and ancillary tests. |
| Databáze: | OpenAIRE |
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