Stereochemical aspects of intramolecular palladium catalysed [3+2] cycloadditions of methylenecyclopropanes

Autor:	Michael Stepp, Alexandra M. Z. Slawin, Hervé Corlay, Andrew M. K. Pennell, David J. Williams, Michael Shipman, William B. Motherwell, Paul Binger
Rok vydání:	1996
Předmět:	Acrylate chemistry.chemical_compound Cyclo addition chemistry Stereochemistry Intramolecular force Organic Chemistry Drug Discovery chemistry.chemical_element Biochemistry Medicinal chemistry Cycloaddition Palladium
Zdroj:	Tetrahedron. 52:4883-4902
ISSN:	0040-4020
DOI:	10.1016/0040-4020(96)00160-3
Popis:	The preparation and intramolecular palladium catalysed [3+2] cycloaddition reactions of a range of substrates containing either stereochemically defined 2,3-disubstituted methylenecyclopropanes 3 or acrylate accepters 12-15 are described. Evidence is presented which supports the hypothesis that these cycloaddition reactions proceed via palladium-trimethylenemethane type intermediates and that the two carbon-carbon bonds are formed in a highly asynchronous manner.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::36c422a197af33bbb491d49830bf86c1 https://doi.org/10.1016/0040-4020(96)00160-3 Zobrazit plný text záznamu Full Text from ScienceDirect