Effects of human recombinant IL-1β on established experimental arthritis in rats

Autor: B. Terlain, Pierre Gillet, P. Netter, J Y Jouzeau, A. Bousseau, P. Fener, Charrière G, E. Drelon
Rok vydání: 1992
Předmět:
Zdroj: Inflammopharmacology. 1:263-282
ISSN: 1568-5608
0925-4692
Popis: Recent studies have reported the ambivalent properties of IL-1, in that it increases or decreases experimental arthritis depending on the dose, the mode, the site, the duration of administration, and the animal model used. In a first experiment we investigated the influence of iterative subcutaneous injections of human recombinant interleukin-1β (HrIL-1β) (0.02, 0.2 or 2 μg) on the inflammatory events in arthritic rats sensitized with type II collagen and muramyl dipeptide. The daily dose of 0.2 μg slightly reduced the pathological response score while 2 μg made it worse; the dose of 0.02 μg was always ineffective. Therefore, the long-term influence of the 0.2 μg dosage of HrIL-1β on the severity of arthritic lesions was investigated. In those experimental conditions, when compared with vehicle only, HrIL-1β slightly reduced hindpaw oedema. This effect was noticeable in severely diseased animals, but was absent in those having moderate swelling. In addition, HrIL-1β induced a delayed relapsing inflammation, whatever the severity of the arthritis. In comparison, indomethacin markedly decreased the early events of inflammation without affecting the delayed relapsing arthritic process.
Databáze: OpenAIRE
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