Comparison of Midodrine and Albumin in the Prevention of Paracentesis-induced Circulatory Dysfunction in Cirrhotic Patients
| Autor: | Ahmed A. ElBaz, Omayma M Hassanin, Ahmed Hassan, Hassan Hamdy |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Effective arterial blood volume
medicine.medical_specialty Cirrhosis medicine.diagnostic_test business.industry Midodrine Gastroenterology medicine.disease Plasma renin activity Hepatorenal syndrome Internal medicine Ascites Paracentesis Medicine medicine.symptom business Intensive care medicine Hepatic encephalopathy medicine.drug |
| Zdroj: | Journal of Clinical Gastroenterology. 48:184-188 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/mcg.0b013e31829ae376 |
| Popis: | GOALS In this pilot study, we compared midodrine and albumin in the prevention of paracentesis-induced circulatory dysfunction (PICD). BACKGROUND PICD with pronounced arterial vasodilatation in cirrhotics with tense ascites can be prevented by the infusion of albumin, which is an expensive treatment modality. Various vasoconstrictors have also been used to prevent PICD, but there are few studies about the usage of midodrine. STUDY Fifty patients with cirrhosis and tense refractory ascites were randomly assigned to be treated with either midodrine (n=25) (12.5 mg 3 times/d; over 3 d) or albumin (n=25) (8 g/L of removed ascites) after a large-volume paracentesis. Effective arterial blood volume was assessed indirectly by measuring serum creatinine, serum sodium, plasma renin activity, and aldosterone concentration before and 6 days after paracentesis. RESULTS Midodrine therapy was cheaper compared with albumin therapy, but serum creatinine, serum sodium, plasma renin activity, and plasma aldosterone concentration values after treatment [0.99±0.19 to 3.02±2.58 mg/dL (P=0.001), 132.36±3.2 to 130.2±4.1 mEq/L (P |
| Databáze: | OpenAIRE |
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