ChemInform Abstract: Pyrazoline Bearing Benzimidazoles: Search for Anticancer Agent

Autor:	Mohammad Mustaqeem Abdullah, Mohammad Shaharyar, Mohammed Afroz Bakht, Jaseela Majeed
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Benzimidazole chemistry Stereochemistry Cell panel Single high dose Hydrazine Pyrazoline General Medicine Pyrazoline derivatives Dose level Hydrate Medicinal chemistry
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201018121
Popis:	2-acetyl benzimidazole was allowed to react with substituted aromatic aldehydes to get desired intermediate chalcones (2a-g), the cyclocondensation of these intermediates with hydrazine hydrate and phenyl hydrazine in two separate reactions yielded pyrazoline derivatives (3a-g &4a-g respectively). Among the synthesize compounds, six compounds were granted NSC code and screened at National Cancer Institute (NCI), USA for anticancer activity at a single high dose (10(-5) M) in full NCI 60 cell panel. Among the selected compounds, (4f) 2-[5-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-3-pyrazolyl]-1H-benzimidazole (NSC 748326) was found to be the most active candidate of the series and selected for further evaluation at five dose level screening.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::36adda89f5b4f10f977081e72ad0f749 https://doi.org/10.1002/chin.201018121 Zobrazit plný text záznamu Plný text