Stage II endometrial carcinoma. Results and complications of a combined radiotherapeutic-surgical approach

Autor: J.P. Kong, H.S. Gallager, Larry J. Copeland, J.T. Wharton, Dale M. Larson, C. A. Stringer
Rok vydání: 1988
Předmět:
Zdroj: Cancer. 61:1528-1534
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(19880415)61:8<1528::aid-cncr2820610808>3.0.co;2-9
Popis: Since one third of the patients with Stage II endometrial carcinoma have occult extrauterine pelvic metastases at diagnosis, adequate treatment must include the pelvic lymph nodes and parametria. Eighty-three patients with Stage II endometrial carcinoma were treated between January 1964 and December 1983. Sixty-nine patients (83%) received combined whole-pelvic irradiation and surgery, five (6%) had surgery alone and nine (11%) had radiotherapy alone. Five-year actuarial survival rates were 67%, 60%, and 38%, respectively. No pelvic recurrence occurred in the 69 patients who received the combined therapy, and there was no vaginal recurrence in the 80 patients treated with intracavity radium. There was a significantly lower incidence of pelvic lymph node metastases (P = 0.03) in patients treated with preoperative irradiation. The median time to recurrence was 17 months, with 67% of the recurrences diagnosed before 2 years, and 88% within 5 years. Ten patients (12%) incurred severe complications and three died as a result. Whole-pelvic irradiation, intracavity radium, and hysterectomy are effective treatment for occult pelvic and vaginal disease.
Databáze: OpenAIRE
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