Prevalence of Microalbuminuria in NIDDM Hypertensives and Non-Diabetic Hypertensives A Comparative Study
| Autor: | Matta SreeVani, Bezwada Srinivasa Rao, G. J. S. L. Latha |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Proteinuria endocrine system diseases biology business.industry Population Hydrostatic pressure nutritional and metabolic diseases Renal function Angiotensin-converting enzyme urologic and male genital diseases medicine.disease Gastroenterology Nephropathy Endocrinology Blood pressure Internal medicine medicine biology.protein Microalbuminuria medicine.symptom education business |
| Zdroj: | IOSR Journal of Pharmacy and Biological Sciences. 9:01-08 |
| ISSN: | 2278-3008 2319-7676 |
| DOI: | 10.9790/3008-09440108 |
| Popis: | Urinary albumin excretion is indicative of glomerular permeability with increasing levels of albumin in the urine indicates renal damage. An excretion rate of 300mg/day is macroalbuminuria. Microalbuminuria of 20-200µg/min (30-300 mg/day) is an early indicator of renal injury and predicts the development of proteinuria and progressive renal failure. Microalbuminuria is also an important predictor of cardiovascular events in patients with both insulin dependent diabetes mellitus (IDDM) and non insulin dependent diabetes mellitus (NIDDM). Urinary albumin excretion depends on permselectivity of the glomerular basement membrane (GBM). Majority of patients with nephropathy have NIDDM due to higher prevalence of NIDDM ( 90% ) in general population. Hypertension accelerates rate of decline of renal function and more closely related to higher blood pressure and longer duration. Increased glomerular hydrostatic pressure and increased permeability of GBM are two proposed mechanisms for increased Urinary Albumin Excretion ( UAE ). The aim of study is to compare the prevalence of microalbuminuria in non insulin dependent diabetic (NIDDM) hypertensives with non-diabetic hypertensives and to correlate with sex, age, family history, body mass index(BMI), mean arterial pressure(MAP) risk factors. Only type2 diabetic hypertensives and non diabetic hypertensives were included. IDDM patients and hypertensives on angiotensin converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARBS) were excluded from the study. 150 persons were enrolled into the study. 50 non insulin dependent diabetic hypertensives, 50 non-diabetic hypertensives and 50 healthy individuals were included as controls. Urinary Albumin Excretion(UAE) was estimated by particle enhanced Immunoturbidimetric test in 24 hr urinary sample. The study showed higher prevalence of microalbuminuria in NIDDM with HTN group (74%) than non-diabetic hypertensive group (38%). Males showed higher prevalence of microalbuminuria 56.75% in NIDDM with HTN and 68.42% in hypertensives than females in both groups. The study showed patients in higher age group 50-60yrs had higher prevalence of microalbuminuria 78.37% in NIDDM with HTN and 63.15% in non diabetic hypertensives. It has been observed that increasing of age associated with increased prevalence of microalbuminuria. 74% of patients in NIDDM with HTN and 54% of patients in non diabetic hypertensives showed positive family history. Higher BMI 25-35 showed higher prevalence of microalbuminuria 67.56% in NIDDM with HTN and 42% in HTN group. Higher prevalence of microalbuminuria 74% in diabetic hypertensives and 38% in non diabetic hypertensives with MAP ranging between 111-150 mmHg. The results were analysed by applying Chi-square test. p-value calculated and compared among three groups. P- value < 0.005 which is highly significant.. |
| Databáze: | OpenAIRE |
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