Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital

Autor:	Syeda Nargis Fatima, Jawed Iqbal, Fatima Ali Khan
Rok vydání:	2018
Předmět:	musculoskeletal diseases Correlation medicine.medical_specialty business.industry Healthy individuals Internal medicine Medicine respiratory system Anthropometry Tertiary care hospital business circulatory and respiratory physiology respiratory tract diseases
Zdroj:	Journal of Bahria University Medical and Dental College. :134-138
ISSN:	2617-9482 2220-7562
DOI:	10.51985/jbumdc2018023
Popis:	Objective: To correlate serum levels of YKL-40 with anthropometric measurements and spirometric indices between normal individuals and asthmatics. Methodology: The case control study was conducted in Department of Chest Medicine, JPMC, Karachi from the month of August 2015 till March 2016. The study recruited sixty participants after satisfying the inclusion and exclusion criteria; among those 30 were normal healthy individuals (PEF > 80% and pulse rate of 60 – 80 beats per minutes); while equal were cases of mild to moderate asthma (PEF more than 50% and pulse rate of 100 – 120 beats per minutes) matched for age and gender. Vitallograph compacta and peak flow meter was used for spirometric indices. Moreover, anthropometric measurements were age, gender, weight (kg), height (m) and body mass index (kg/m2). Ykl-40 Elisa kit was used for serum YKL 40 levels. The data was entered and analysed using SPSS version 21 (IBM, Chicago, IL). Result: In comparison of Spirometric Evaluation (FEV1, FVC, FEV1/FVC% and PEFR) between control and patients with mild to moderate asthma. significant difference was found in the mean values of FEV1, FVC, FEV1/FVC and PEFR between cases and controls. Significant inverse correlation was found between YKL-40 with FEV1, FVC, FEVI/FVC% and PEFR among Controls. YKL-40 was found to be significantly correlated with only FEV1/ FVC (%) among cases with correlation co-efficient as – 0.510 (p-value < 0.004). Conclusion: There is an inverse correlation between serum YKL-40 levels and spirometric evaluation thus as the inflammation in asthma increases, YKL-40 level upsurges and causes decrease in lung function tests.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::369dc911c77cef58ca4739502afb6b5b https://doi.org/10.51985/jbumdc2018023 Zobrazit plný text záznamu