Placental massive perivillous fibrinoid deposition is associated with adverse pregnancy outcomes: a clinicopathological study of 12 cases
| Autor: | Maili Qi, Derrick W. Q. Lian, Kenneth Tou En Chang, Kok Hian Tan, Chong Kiat Khoo |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Embryology medicine.medical_specialty 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology Perinatal outcome 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Placenta Pediatrics Perinatology and Child Health Medicine business Pregnancy outcomes Deposition (chemistry) |
| Zdroj: | Case Reports in Perinatal Medicine. 5:35-39 |
| ISSN: | 2192-8959 2192-8932 |
| DOI: | 10.1515/crpm-2015-0087 |
| Popis: | Introduction: Massive perivillous fibrinoid deposition (MPFD) is a very rare placental condition characterized by abnormally extensive fibrinoid deposition in the placental villous parenchyma. The aim of this study is to document clinical and pathological features with special focus on pregnancy outcomes of this condition in consecutive cases of MPFD in our local population. Methods: This is a retrospective clinico-pathological study of cases affected by MPFD over the period January 2010–July 2014 in our hospital. We document clinical features (including perinatal outcome and subsequent pregnancies) and placental pathological characteristics. Results: Twelve cases of MPFD were identified among 3640 placentas (0.33%). There was no identified recurrence. The affected infants had adverse outcomes, including intrauterine growth restriction (IUGR) (75%), preterm birth (58.3%), and fetal loss (25%). A high frequency of reduced PAPP-A in the first trimester (25%), and concurrent gestational hypertension or pre-eclampsia (25%) was noted. Conclusion: MPFD is associated with adverse perinatal outcomes. Further research to better understand its pathogenesis and to improve clinical diagnosis and management is warranted. |
| Databáze: | OpenAIRE |
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