Common Y-chromosomal STR database for three closely related European populations

Autor:	Krzysztof Rębała, Zofia Szczerkowska, Daniela Siváková, A. I. Mikulich, Zuzana Džupinková, Iosif S. Tsybovsky
Rok vydání:	2006
Předmět:	Genetics Database Haplotype General Medicine Polish population Biology computer.software_genre Analysis of molecular variance law.invention law Microsatellite Multiplex computer Polymerase chain reaction
Zdroj:	International Congress Series. 1288:177-179
ISSN:	0531-5131
Popis:	Eighteen Y-chromosomal microsatellite loci (DYS19, DYS388, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS426, DYS437, DYS438, DYS439, DYS460, GATA H4.1, DYS385 a/b, YCAII a/b) were analyzed in 568 males from Belarus, Poland and Slovakia by means of a multiplex (octadecaplex) PCR reaction and capillary electrophoresis in order to compare their usefulness in forensic practice individually and in a haplotype format. Analysis of molecular variance (AMOVA) revealed significant differences between the three populations and excluded one common Y-STR database. Markers responsible for the differences between populations were identified using a chi-square test for homogeneity and locus-by-locus AMOVA. Selection of loci showing homogeneity enabled establishment of a common haplotype database for the studied populations. This approach may become an efficient method for Y-STR databasing for larger ethnogeographic areas as soon as consecutive homogeneity-showing markers are identified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::36958c09382b417fb94f234256108dfb https://doi.org/10.1016/j.ics.2005.09.120 Zobrazit plný text záznamu Full Text from ScienceDirect